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| Saturday, October 25th , 2025 |
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| Promoted RP Matty Artiles to Major League Key West. |
| Fired Hitting Coach Arion Browne. |
| Signed Pitching Coach Carlos Rhomberg to a 2-year contract extension. |
| Monday, October 6th , 2025 |
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| Released RP Gerald McBrayer. |
| Released C Aurelio Segveira. |
| Promoted RP José Acosta to Triple A Glendale. |
| Promoted RP Javier Ortegas to Triple A Glendale. |
| Promoted RP Doug Townley to Triple A Glendale. |
| Promoted C Tim Adrian to Triple A Glendale. |
| Promoted C Bobby MacKellaigh to Triple A Glendale. |
| Promoted 2B Brandon Elkins to Triple A Glendale. |
| Promoted 3B Lon Ramos to Triple A Glendale. |
| Promoted SS Taffy Robinson to Triple A Glendale. |
| Promoted SP Mervin Rinker to Triple A Glendale. |
| Promoted SP Ramón Camacho to Triple A Glendale. |
| Promoted SP Virgilio Dearo to Triple A Glendale. |
| Promoted SP William Bontein to Triple A Glendale. |
| Received RP Alfredo Narcho from Triple A Glendale. |
| Received RP António Rodríguez from Class A Pittsburgh. |
| Received SP Kalkin Laplante from Class A Pittsburgh. |
| Received SP Matsusuke Saikawa from Class A Pittsburgh. |
| Received RP Donald Overby from Class A Pittsburgh. |
| Received 3B Chester Hyatt from Triple A Glendale. |
| Received SS Jackie Ramíres from Triple A Glendale. |
| Received SP Hoyt Aspera from Class A Pittsburgh. |
| Received SP Consuelo Tovanche from Class A Pittsburgh. |
| Received RP Katsunan Karamorita from Class A Pittsburgh. |
| Received 1B Juan Barahana from Class A Pittsburgh. |
| Received SP Jorge García from Class A Pittsburgh. |
| Received 1B Andrés Palomarez from Class A Pittsburgh. |
| Released RP Ralph Wells. |
| Released 2B Chester Hyatt. |
| Promoted SP Bruno Costello to Triple A Glendale. |
| Promoted CF Kevin Oliver to Triple A Glendale. |
| Received RP Larry Shenton from Triple A Glendale. |
| Received C Omer Horn from Class A Pittsburgh. |
| Received SP Ximen Coracia from Class A Pittsburgh. |
| Monday, September 1st , 2025 |
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| Promoted 2B Erón Purg to Major League Key West. |
| Promoted CF Fitz Griffey to Major League Key West. |
| Promoted LF Dennis Carter to Major League Key West. |
| Released RP António Rodríguez. |
| Promoted RP Ralph Wells to Triple A Glendale. |
| Promoted RP Rad Clark to Triple A Glendale. |
| Promoted RP Éric Monette to Triple A Glendale. |
| Promoted C Aurelio Segveira to Triple A Glendale. |
| Promoted 3B Juan Martínez to Triple A Glendale. |
| Promoted CF Ottavio Tuhell to Triple A Glendale. |
| Promoted 3B Dorsett Hutton to Triple A Glendale. |
| Promoted SP Ralph Turnage to Triple A Glendale. |
| Promoted 1B Will Leffler to Triple A Glendale. |
| Received C Cristófor Ferras from Class A Pittsburgh. |
| Received RF Xiao-yan Yang from Class A Pittsburgh. |
| Received 1B Steven MacFarquhar from Class A Pittsburgh. |
| Received 3B Timoteo Castillo from Class A Pittsburgh. |
| Received RF Carey Kunkel from Class A Pittsburgh. |
| Received 2B Jitendra Bridgewater from Class A Pittsburgh. |
| Received SP Mervin Rinker from Class A Pittsburgh. |
| Received SP Terrell Horan from Class A Pittsburgh. |
| Received C Jeff Broughman from Class A Pittsburgh. |
| Received SP Neifi Grateda from Class A Pittsburgh. |
| Received LF Javier Romero from Class A Pittsburgh. |
| Received SS Howard Ballou from Class A Pittsburgh. |
| Received SS Nees Buizer from Class A Pittsburgh. |
| Received SP Hoyt Aspera from Class A Pittsburgh. |
| Released RP Bob Flack. |
| Promoted CF Tim Saca to Triple A Glendale. |
| Received SP José Acosta from Triple A Glendale. |
| Received RP Soshitsu Shitamura from Triple A Glendale. |
| Received CF Dennis Bojay from Class A Pittsburgh. |
| Received SP Matty Artiles from Class A Pittsburgh. |
| Demoted RP Donald Overby to Class A Pittsburgh. |
| Demoted RP Kalkin Laplante to Class A Pittsburgh. |
| Demoted RP Ximen Coracia to Class A Pittsburgh. |
| Demoted CL Hoyt Aspera to Class A Pittsburgh. |
| Wednesday, August 27th , 2025 |
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| Received CF Fitz Griffey from Triple A Glendale. |
| Monday, August 25th , 2025 |
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| C Kevin Mayers retired from professional baseball. |
| Activated SP Ralph Wells from the injured list. |
| Activated SP Ramón Camacho from the injured list. |
| Activated SP Donzel García from the injured list. |
